Health Ministry bans 344 drugs

The Health Ministry has banned 344 fixed drug combinations through a gazette notification issued over the weekend. These include several common cough syrup solutions,analgesics and antibiotic combinations, many of which are sold over the counter.

The ban, which comes into effect immediately, follows recommendations of an expert committee formed to examine the efficacy of these drug combinations. The industry though may question the basis of the ban and seek judicial intervention.

The list of banned drugs includes Nimesulide, which had been a cause of concern for long for health experts for its continued use in India despite being banned in most of the developed nations. Fixed drug combinations have mushroomed in the market as companies in their quest for newer products — and often to beat price control — mix and match ingredients into a single molecule to market them as newer remedies.

Fixed drug combinations have mushroomed in the market as companies in their quest for newer products — and often to beat price control — mix and match ingredients into a single molecule to market them as newer remedies. 

Here is the complete list of all drug combinations banned by the ministry:

* fixed dose combination of Aceclofenac + Paracetamol + Rabeprazole

* fixed dose combination of Nimesulide + Diclofenac

* fixed dose combination of Nimesulide + Cetirizine + Caffeine

* fixed dose combination of Nimesulide + Tizanidine

* fixed dose combination of Paracetamol + Cetirizine + Caffeine

* fixed dose combination of Diclofenac + Tramadol + Chlorzoxazone

* fixed dose combination of Dicyclomine + Paracetamol + Domperidone

* fixed dose combination of Nimesulide + Paracetamol dispersible tablets

* fixed dose combination of Paracetamol + Phenylephrine + Caffeine

* fixed dose combination of Diclofenac + Tramadol + Paracetamol

* fixed dose combination of Diclofenac + Paracetamol + Chlorzoxazone + Famotidine

* fixed dose combination of Naproxen + Paracetamol

* fixed dose combination of Nimesulide + Serratiopeptidase

* fixed dose combination of Paracetamol + Diclofenac + Famotidine

* fixed dose combination of Nimesulide + Pitofenone + Fenpiverinium + Benzyl Alcohol

* fixed dose combination of Omeprazole + Paracetamol + Diclofenac

* fixed dose combination of Nimesulide + Paracetamol injection

* fixed dose combination of Tamsulosin + Diclofenac

* fixed dose combination of Paracetamol + Phenylephrine + Chlorpheniramine + Dextromethorphan + Caffeine

* fixed dose combination of Diclofenac + Zinc Carnosine

* fixed dose combination of Diclofenac + Paracetamol + Chlorpheniramine Maleate + Magnesium Trisillicate

* fixed dose combination of Paracetamol + Pseudoephedrine + Cetrizine

* fixed dose combination of Phenylbutazone + Sodium Salicylate

* fixed dose combination of Lornoxicam + Paracetamol + Trypsin

* fixed dose combination of Paracetamol + Mefenamic Acid + Ranitidine + Dicyclomine

* fixed dose combination of Nimesulide + Dicyclomine

* fixed dose combination of Heparin + Diclofenac

* fixed dose combination of Glucosamine + Methyl Sulfonyl Methane + Vitamin D3 + Manganese + Boron + Copper + Zinc

* fixed dose combination of Paracetamol + Tapentadol

* fixed dose combination of Tranexamic Acid + Proanthocyanidin

* fixed dose combination of Benzoxonium Chloride + Lidocaine

* fixed dose combination of Lornoxicam + Paracetamol + Tramadol

* fixed dose combination of Lornoxicam + Paracetamol + Serratiopeptidase

* fixed dose combination of Diclofenac + Paracetamol + Magnesium Trisilicate

* fixed dose combination of Paracetamol + Domperidone + Caffeine

* fixed dose combination of Ammonium Chloride + Sodium Citrate + Chlorpheniramine Maleate + Menthol

* fixed dose combination of Paracetamol + Prochlorperazine Maleate

* Combikit of 3 tablets of Serratiopeptidase (enteric coated 20000 units) + Diclofenac Potassium & 2 tablets of Doxycycline

* fixed dose combination of Nimesulide + Paracetamol Suspension

* fixed dose combination of Aceclofenac + Paracetamol + Famotidine

* fixed dose combination of Aceclofenac + Zinc Carnosine

* fixed dose combination of Paracetamol + Disodium Hydrogen Citrate + Caffeine

* fixed dose combination of Paracetamol + DL Methionine

* fixed dose combination of Disodium Hydrogen Citrate + Paracetamol

* fixed dose combination of Paracetamol + Caffeine + Codeine

* fixed dose combination of Aceclofenac (SR) + Paracetamol

* fixed dose combination of Diclofenac + Paracetamol injection

* fixed dose combination of Azithromycin + Cefixime

* fixed dose combination of Amoxicillin + Dicloxacillin

* fixed dose combination of Amoxicillin 250 mg + Potassium Clavulanate Diluted 62.5 mg

* fixed dose combination of Azithromycin + Levofloxacin

* fixed dose combination of Cefixime + Linezolid

* fixed dose combination of Amoxicillin + Cefixime + Potassium Clavulanic Acid

* fixed dose combination of Ofloxacin + Nitazoxanide

* fixed dose combination of Cefpodoxime Proxetil + Levofloxacin * Combikit of Azithromycin, Secnidazole and Fluconazole

* fixed dose combination of Levofloxacin + Ornidazole + Alpha Tocopherol Acetate

* fixed dose combination of Nimorazole + Ofloxacin

* fixed dose combination of Azithromycin + Ofloxacin

* fixed dose combination of Amoxycillin + Tinidazole

* fixed dose combination of Doxycycline + Serratiopeptidase

* fixed dose combination of Cefixime + Levofloxacin

* fixed dose combination of Ofloxacin + Metronidazole + Zinc Acetate

* fixed dose combination of Diphenoxylate + Atropine + Furazolidone * Combikit of Fluconazole Tablet, Azithromycin Tablet and Ornidazole Tablets

* fixed dose combination of Ciprofloxacin + Phenazopyridine

* fixed dose combination of Amoxycillin + Dicloxacillin + Serratiopeptidase * Combikit of Fluconazole Tablet, Azithromycin Tablet and Ornidazole Tablets

* fixed dose combination of Ciprofloxacin + Phenazopyridine

* fixed dose combination of Amoxycillin + Dicloxacillin + Serratiopeptidase

* fixed dose combination of Azithromycin + Cefpodoxime

* fixed dose combination of Lignocaine + Clotrimazole + Ofloxacin + Beclomethasone

* fixed dose combination of Cefuroxime + Linezolid

* fixed dose combination of Ofloxacin + Ornidazole + Zinc Bisglycinate

* fixed dose combination of Metronidazole + Norfloxacin

* fixed dose combination of Amoxicillin + Bromhexine

* fixed dose combination of Ciprofloxacin + Fluticasone + Clotrimazole + Neomycin

* fixed dose combination of Metronidazole + Tetracycline

* fixed dose combination of Cephalexin + Neomycin + Prednisolone

* fixed dose combination of Azithromycin + Ambroxol

* fixed dose combination of Cilnidipine + Metoprolol Succinate + Metoprolol Tartrate

* fixed dose combination of L-Arginine + Sildenafil

* fixed dose combination of Atorvastatin + Vitamin D3 + Folic Acid + Vitamin B12 + Pyridoxine

* fixed dose combination of Metformin + Atorvastatin

* fixed dose combination of Clindamycin + Telmisartan

* fixed dose combination of Olmesartan + Hydrochlorothiazide + Chlorthalidone

* fixed dose combination of L-5-Methyltetrahydrofolate Calcium + Escitalopram i

* fixed dose combination of Pholcodine + Promethazine

* fixed dose combination of Paracetamol + Promethazine

* fixed dose combination of Betahistine + Ginkgo Biloba Extract + Vinpocetine + Piracetam

* fixed dose combination of Cetirizine + Diethyl Carbamazine

* fixed dose combination of Doxylamine + Pyridoxine + Mefenamic Acid + Paracetamol

* fixed dose combination of Drotaverine + Clidinium + Chlordiazepoxide

* fixed dose combination of Imipramine + Diazepam

* fixed dose combination of Flupentixol + Escitalopram

* fixed dose combination of Paracetamol + Prochloperazine

* fixed dose combination of Gabapentin + Mecobalamin + Pyridoxine + Thiamine

* fixed dose combination of Imipramine + Chlordiazepoxide + Trifluoperazine + Trihexyphenidyl

* fixed dose combination of Chlorpromazine + Trihexyphenidyl

* fixed dose combination of Ursodeoxycholic Acid + Silymarin

* fixed dose combination of Metformin 1000/1000/500/500mg + Pioglitazone 7.5/7.5/7.5/7.5mg + Glimepiride 1/2/1/2mg

* fixed dose combination of Gliclazide 80 mg + Metformin 325 mg

* fixed dose combination of Voglibose+ Metformin + Chromium Picolinate

* fixed dose combination of Pioglitazone 7.5/7.5mg + Metformin 500/1000mg

* fixed dose combination of Glimepiride 1mg/2mg/3mg + Pioglitazone 15mg/15mg/15mg + Metformin 1000mg/ 1000mg/1000mg

* fixed dose combination of Glimepiride 1mg/2mg+ Pioglitazone 15mg/15mg + Metformin 850mg/850mg

* fixed dose combination of Metformin 850mg + Pioglitazone 7.5 mg + Glimepiride 2mg

* fixed dose combination of Metformin 850mg + Pioglitazone 7.5 mg + Glimepiride 1mg

* fixed dose combination of Metformin 500mg/500mg+Gliclazide SR 30mg/60mg + Pioglitazone 7.5mg/7.5mg

* fixed dose combination of Voglibose + Pioglitazone + Metformin

* fixed dose combination of Metformin + Bromocriptine

* fixed dose combination of Metformin + Glimepiride + Methylcobalamin

* fixed dose combination of Pioglitazone 30 mg + Metformin 500 mg

* fixed dose combination of Glimepiride + Pioglitazone + Metformin

* fixed dose combination of Glipizide 2.5mg + Metformin 400 mg

* fixed dose combination of Pioglitazone 15mg + Metformin 850 mg

* fixed dose combination of Metformin ER + Gliclazide MR + Voglibose

* fixed dose combination of Chromium Polynicotinate + Metformin

* fixed dose combination of Metformin + Gliclazide + Piogllitazone + Chromium Polynicotinate

* fixed dose combination of Metformin + Gliclazide + Chromium Polynicotinate

* fixed dose combination of Glibenclamide + Metformin (SR)+ Pioglitazone

* fixed dose combination of Metformin (Sustainded Release) 500mg + Pioglitazone 15 mg + Glimepiride 3mg

* fixed dose combination of Metformin (SR) 500mg + Pioglitazone 5mg

* fixed dose combination of Chloramphenicol + Beclomethasone + Clomitrimazole + Lignocaine

* fixed dose combination of Clotrimazole + Ofloxaxin + Lignocaine + Glycerine and Propylene Glycol

* fixed dose combination of Chloramphennicol + Lignocaine + Betamethasone + Clotrimazole + Ofloxacin + Antipyrine

* fixed dose combination of Ofloxacin + Clotrimazole + Betamethasone + Lignocaine

* fixed dose combination of Gentamicin Sulphate + Clotrimazole + Betamethasone + Lignocaine

* fixed dose combination of Clotrimazole + Beclomethasone + Ofloxacin + Lignocaine

* fixed dose combination of Becloemthasone + Clotrimazole + Chloramphenicol + Gentamycin + Lignocaine Ear drops

* fixed dose combination of Flunarizine + Paracetamole + Domperidone

* fixed dose combination of Rabeprazole + Zinc Carnosine

* fixed dose combination of Magaldrate + Famotidine + Simethicone

* fixed dose combination of Cyproheptadine + Thiamine

* fixed dose combination of Magaldrate + Ranitidine + Pancreatin + Domperidone

* fixed dose combination of Ranitidine + Magaldrate + Simethicone

* fixed dose combination of Magaldrate + Papain + Fungul Diastase + Simethicone

* fixed dose combination of Rabeprazole + Zinc + Domperidone

* fixed dose combination of Famotidine + Oxytacaine + Magaldrate

* fixed dose combination of Ranitidine + Domperidone + Simethicone

* fixed dose combination of Alginic Acid + Sodium Bicarbonate + Dried Aluminium Hydroxide + Magnesium Hydroxide

* fixed dose combination of Clidinium + Paracetamol + Dicyclomine + Activated Dimethicone

* fixed dose combination of Furazolidone + Metronidazole + Loperamide

* fixed dose combination of Rabeprazole + Diclofenac + Paracetamol

* fixed dose combination of Ranitidine + Magaldrate

* fixed dose combination of Norfloxacin + Metronidazole + Zinc Acetate

* fixed dose combination of Zinc Carnosine + Oxetacaine

* fixed dose combination of Oxetacaine + Magaldrate + Famotidine

* fixed dose combination of Pantoprazole (as Enteric Coated Tablet) + Zinc Carnosine (as Film Coated Tablets)

* fixed dose combination of Zinc Carnosine + Magnesium Hydroxide + Dried Aluminium Hydroxide + Simethicone

* fixed dose combination of Zinc Carnosine + Sucralfate

* fixed dose combination of Mebeverine & Inner HPMC capsule (Streptococcus Faecalis + Clostridium butyricum + Bacillus mesentricus + Lactic Acid Bacillus)

* fixed dose combination of Clindamycin + Clotrimazole + Lactic Acid Bacillus

* fixed dose combination of Sildenafil + Estradiol Valerate

* fixed dose combination of Clomifene Citrate + Ubidecarenone + Zinc + Folic Acid + Methylcobalamin + Pyridoxine + Lycopene + Selenium + Levocarnitine Tartrate + L-

Arginine

* fixed dose combination of Thyroxine + Pyridoxine + Folic Acid

* fixed dose combination of Gentamycin + Dexamethasone + Chloramphenicol + Tobramycin + Ofloxacin

* fixed dose combination of Dextromethorphan + Levocetirizine + Phenylephrine + Zinc

* fixed dose combination of Nimesulide + Loratadine + Phenylephrine + Ambroxol

* fixed dose combination of Bromhexine + Phenylephrine + Chlorepheniramine Maleate

* fixed dose combination of Dextromethorphan + Bromhexine + Guaiphenesin

* fixed dose combination of Paracetamol + Loratadine + Phenylephrine + Dextromethorphan + Caffeine

* fixed dose combination of Nimesulide + Phenylephrine + Caffeine + Levocetirizine

* fixed dose combination of Azithromycin + Acebrophylline

* fixed dose combination of Diphenhydramine + Terpine + Ammonium Chloride + Sodium Chloride + Menthol

* fixed dose combination of Nimesulide + Paracetamol + Cetirizine + Phenylephrine

* fixed dose combination of Paracetamol + Loratadine + Dextromethophan + Pseudoepheridine + Caffeine

* fixed dose combination of Chlorpheniramine Maleate + Dextromethorphan + Dextromethophan + Guaiphenesin + Ammonium Chloride + Menthol

* fixed dose combination of Chlorpheniramine Maleate + Ammonium Chloride + Sodium Citrate

* fixed dose combination of Cetirizine + Phenylephrine + Paracetamol + Zinc Gluconate

* fixed dose combination of Ambroxol + Guaiphenesin + Ammonium Chloride + Phenylephrine + Chlorpheniramine Maleate + Menthol

* fixed dose combination of Dextromethorphen + Bromhexine + Chlorpheniramine Maleate + Guaiphenesin

* fixed dose combination of Levocetirizine + Ambroxol + Phenylephrine + Guaiphenesin

* fixed dose combination of Dextromethorphan + Chlorpheniramine + Chlorpheniramine Maleate

* fixed dose combination of Cetirizine + Ambroxol + Guaiphenesin + Ammonium Chloride + Phenylephrine + Menthol

* fixed dose combination of Chlorpheniramine + Phenylephrine + Caffeine

* fixed dose combination of Dextromethorphan + Triprolidine + Phenylephrine

* fixed dose combination of Terpinhydrate + Dextromethorphan + Menthol

* fixed dose combination of Dextromethorphan + Phenylephrine + Zinc Gluconate + Menthol

* fixed dose combination of Chlorpheniramine + Codeine + Sodium Citrate + Menthol Syrup

* fixed dose combination of Enrofloxacin + Bromhexin

* fixed dose combination of Bromhexine + Dextromethorphan + Phenylephrine + Menthol

* fixed dose combination of Levofloxacin + Bromhexine

* fixed dose combination of Levocetirizine + Ranitidine

* fixed dose combination of Levocetirizine + Phenylephrine + Ambroxol + Guaiphenesin + Paracetamol

* fixed dose combination of Cetirizine + Dextromethorphan + Phenylephrine + Zinc Gluconate + Paracetamol + Menthol

* fixed dose combination of Paracetamol + Pseudoephedrine + Dextromethorphan + Cetirizine

* fixed dose combination of Diphenhydramine + Guaiphenesin + Ammonium Chloride + Bromhexine

* fixed dose combination of Chlorpheniramine + Dextromethorphan + Phenylephrine + Paracetamol

* fixed dose combination of Dextromethorphen + Promethazine

* fixed dose combination of Diethylcabamazine Citrate + Cetirizine + Guaiphenesin

* fixed dose combination of Pseudoephedrine + Dextromethorphan + Cetirizine

* fixed dose combination of Chlorpheniramine + Phenylephrine + Dextromethophan + Menthol

* fixed dose combination of Ambroxol + Terbutaline + Dextromethorphan

* fixed dose combination of Dextromethorphan + Chlorpheniramine + Guaiphenesin

* fixed dose combination of Terbutaline + Bromhexine + Guaiphenesin + Dextromethorphan

* fixed dose combination of Dextromethorphan + Tripolidine + Phenylephirine

* fixed dose combination of Paracetamol + Dextromethorphan + Chlorpheniramine

* fixed dose combination of Pholcodine + Phenylephrine + Promethazine

* fixed dose combination of Codeine + Levocetirizine + Menthol

* fixed dose combination of Dextromethorphan + Ambroxol + Guaifenesin + Phenylephrine + Chlorpheniramine

* fixed dose combination of Cetirizine + Phenylephrine + Dextromethorphan + Menthol

* fixed dose combination of Roxithromycin + Serratiopeptidase

* fixed dose combination of Paracetamol + Phenylephrine + Triprolidine

* fixed dose combination of Acetaminophen + Loratadine + Ambroxol + Phenylephrine

* fixed dose combination of Cetirizine + Acetaminophen + Dextromethorphan + Phenyephrine + Zinc Gluconate

* fixed dose combination of Diphenhydramine + Guaifenesin + Bromhexine + Ammonium Chloride + Menthol

* fixed dose combination of Chlopheniramine Maleate + Codeine Syrup

* fixed dose combination of Cetirizine + Dextromethorphan + Zinc Gluconate + Menthol

* fixed dose combination of Paracetamol + Phenylephrine + Desloratadine + Zinc Gluconate + Ambroxol

* fixed dose combination of Levocetirizine + Montelukast + Acebrophylline

* fixed dose combination of Dextromethorphan + Phenylephrine + Ammonium Chloride + Menthol

* fixed dose combination of Dextromethorphan + Bromhexine + Guaiphenesin + Menthol

* fixed dose combination of Acrivastine + Paracetamol + Caffeine + Phenylephrine

* fixed dose combination of Naphazoline + Carboxy Methyl Cellulose + Menthol + Camphor + Phenylephrine

* fixed dose combination of Dextromethorphan + Cetirizine

* fixed dose combination of Nimesulide + Paracetamol + Levocetirizine + Phenylephrine + Caffeine

* fixed dose combination of Terbutaline + Ambroxol + Guaiphenesin + Zinc + Menthol

* fixed dose combination of Codeine + Chlorpheniramine + Alcohol Syrup

* fixed dose combination of Dextromethorphan + Phenylephrine + Guaifenesin + Triprolidine

* fixed dose combination of Ammomium Chloride + Bromhexine + Dextromethorphan

* fixed dose combination of Diethylcarbamazine + Cetirizine + Ambroxol

* fixed dose combination of Ethylmorphine + Noscapine + Chlorpheniramine

* fixed dose combination of Cetirizine + Dextromethorphan + Ambroxol

* fixed dose combination of Bromhexine + Dextromethorphan + Ammonium Chloride + Menthol

* fixed dose combination of Ambroxol + Guaifenesin + Phenylephrine + Chlorpheniramine

* fixed dose combination of Paracetamol + Phenylephrine + Chlorpheniramine + Zinc Gluconate

* fixed dose combination of Dextromethorphan + Phenylephrine + Cetirizine + Paracetamol + Caffeine

* fixed dose combination of Dextromethophan + Chlorpheniramine + Guaifenesin + Ammonium Chloride

* fixed dose combination of Levocetirizine + Dextromethorphan + Zinc

* fixed dose combination of Paracetamol + Phenylephrine + Levocetirizine + Caffeine

* fixed dose combination of Chlorphaniramine + Ammonium Chloride + Sodium Chloride

* fixed dose combination of Paracetamol + Dextromethorphan + Bromhexine + Phenylephrine + Diphenhydramine

* fixed dose combination of Salbutamol + Bromhexine + Guaiphenesin + Menthol

* fixed dose combination of Chlorpheniramine + Ammonium Chloride + Noscapine + Sodium Citrate

* fixed dose combination of Cetirizine + Dextromethorphan + Bromhexine + Guaifenesin

* fixed dose combination of Diethyl Carbamazine + Chlorpheniramine + Guaifenesin

* fixed dose combination of Ketotifen + Cetirizine

* fixed dose combination of Terbutaline + Bromhexine + Etofylline

* fixed dose combination of Ketotifen + Theophylline

* fixed dose combination of Ambroxol + Salbutamol + Theophylline

* fixed dose combination of Cetririzine + Nimesulide + Phenylephrine

* fixed dose combination of Chlorpheniramine + Phenylephrine + Paracetamol + Zink Gluconate

* fixed dose combination of Acetaminophen + Guaifenesin + Dextromethorphan + Chlorpheniramine

* fixed dose combination of Cetirizine + Dextromethorphan + Phenylephrine + Tulsi

* fixed dose combination of Cetirizine + Phenylephrine + Paracetamol + Ambroxol + Caffeine

* fixed dose combination of Guaifenesin + Dextromethorphan

* fixed dose combination of Levocetirizine + Paracetamol + Phenylephirine + Caffeine

* fixed dose combination of Caffeine + Paracetamol + Phenylephrine + Chlorpheniramine

* fixed dose combination of Ketotifen + Levocetrizine

* fixed dose combination of Paracetamol + Levocetirizine + Phenylephirine + Zink Gluconate

* fixed dose combination of Paracetamol + Phenylephrine + Triprolidine + Caffeine

* fixed dose combination of Caffeine + Paracetamol + Phenylephrine + Cetirizine

* fixed dose combination of Caffeine + Paracetamol + Chlorpheniramine

* fixed dose combination of Ammonium Chloride + Dextromethorphan + Cetirizine + Menthol

* fixed dose combination of Dextromethorphan + Paracetamol + Cetirizine + Phenylephrine

* fixed dose combination of Chlorpheniramine + Terpin + Antimony Potassium Tartrate + Ammonium Chloride + Sodium Citrate + Menthol

* fixed dose combination of Terbutaline + Etofylline + Ambroxol

* fixed dose combination of Paracetamol + Codeine + Chlorpheniramine

* fixed dose combination of Paracetamol+Pseudoephedrine+Certirizine+Caffeine

* fixed dose combination of Chlorpheniramine+Ammonium Chloride + Menthol

* fixed dose combination of N-Acetyl Cysteine + Ambroxol + Phenylephrine + Levocertirizine

* fixed dose combination of Dextromethorphan + Phenylephrine + Tripolidine + Menthol

* fixed dose combination of Salbutamol + Certirizine + Ambroxol

* fixed dose combination of Dextromethorphan + Phenylephrine + Bromhexine + Guaifenesin + Chlorpheniramine

* fixed dose combination of Nimesulide + Certirizine + Phenylephrine

* fixed dose combination of Naphazoline + Chlorpheniramine + Zinc Sulphate + Boric Acid + Sodium Chloride + Chlorobutol

* fixed dose combination of Paracetamol + Bromhexine + Phenylephrine + Chlorpheniramine + Guaifenesin

* fixed dose combination of Salbutamol + Bromhexine

* fixed dose combination of Dextromethorphan + Phenylephrine + Guaifenesin + Certirizine + Acetaminophen

* fixed dose combination of Guaifenesin + Bromhexine + Chlorpheniramine + Paracetamol

* fixed dose combination of Chlorpheniramine + Ammonium Chloride + Chloroform + Menthol

* fixed dose combination of Salbutamol + Choline Theophylinate + Ambroxol

* fixed dose combination of Chlorpheniramine + Codeine Phosphate + Menthol Syrup

* fixed dose combination of Pseudoephedrine + Bromhexine

* fixed dose combination of Certirizine + Phenylephrine + Paracetamol + Caffeine + Nimesulide

* fixed dose combination of Dextromethorphan + Cetirizine + Guaifenesin + Ammonium Chloride

* fixed dose combination of Ambroxol + Salbutamol + Choline Theophyllinate + Menthol

* fixed dose combination of Paracetamol + Chlorpheniramine + Ambroxol + Guaifenesin + Phenylephrine

* fixed dose combination of Chlorpheniramine + Vasaka + Tolubalsm + Ammonium Chloride + Sodium Citrate + Menthol

* fixed dose combination of Bromhexine + Cetrizine + Phenylephrine IP+Guaifenesin + Menthol

* fixed dose combination of Dextromethorphan + Ambroxol + Ammonium Chloride + Chlorpheniramine + Menthol

* fixed dose combination of Dextromethorphan + Phenylephrine + Cetirizine + Zinc + Menthol

* fixed dose combination of Terbutaline + N-Acetyl L-Cysteine + Guaifenesin

* fixed dose combination of Calcium Gluconate + Levocetirizine

* fixed dose combination of Paracetamol + Levocetirizine + Pseudoephedrine

* fixed dose combination of Salbutamol + Choline Theophylinate + Carbocisteine

* fixed dose combination of Chlorpheniramine + Vitamin C

* fixed dose combination of Calcium Gluconate + Chlorpheniramine + Vitamin C

* fixed dose combination of Chlorpheniramine + Paracetamol + Pseudoephedrine + Caffeine

* fixed dose combination of Guaifenesin + Bromhexine + Chlorpheniramine + Phenylephrine + Paracetamol + Serratiopeptidase (as enteric coated granules) 10000 SP Units

* fixed dose combination of Paracetamol + Pheniramine

* fixed dose combination of Betamethasone + Fusidic Acid + Gentamycin + Tolnaftate + lodochlorhydroxyquinoline (ICHQ)

* fixed dose combination of Clobetasol + Ofloxacin + Miconazole + Zinc Sulphate

* fixed dose combination of Clobetasole + Gentamicin + Miconazole + Zinc Sulphate

* fixed dose combination of Levocetirizine + Ambroxol + Phenylephrine + Paracetamol

* fixed dose combination of Permethrin + Cetrimide + Menthol

* fixed dose combination of Beclomethasone + Clotimazole + Neomycin + lodochlorohydroxyquinone

* fixed dose combination of Neomycin + Doxycycline

* fixed dose combination of Ciprofloxacin + Fluocinolone + Clotrimazole + Neomycin + Chlorocresol

* fixed dose combination of Clobetasol + Ofloxacin + Ketoconazol + Zinc Sulphate

* fixed dose combination of Betamethasone + Gentamicin + Tolnaftate + lodochlorhydroxyquinoline

* fixed dose combination of Clobetasol + Gentamicin + Tolnaftate + lodochlorhydroxyquinone + Ketoconazole

* fixed dose combination of Allantoin + Dimethieone + Urea + Propylene + Glycerin + Liquid Paraffin

* fixed dose combination of Acriflavine + Thymol + Cetrimide

* fixed dose combination of Betamethasone + Neomycin + Tolnaftate + lodochlorohydroxyquinoline + Cholorocresol

* fixed dose combination of Clobetasol + Neomycin + Miconazole + Clotrimazole

* fixed dose combination of Ketoconazole + Tea Tree oil + Allantion + Zinc Oxide + Aloe Vera + Jojoba oil + Lavander oil + Soa noodels

* fixed dose combination of Clobetasol Propionate + Ofloxacin + Ornidazole + Terbinafine

* fixed dose combination of Clobetasol + Neomycin + Miconazole + Zinc Sulphate

* fixed dose combination of Beclomethasone Diproprionate + Neomycin + Tolnaftate + lodochlorhydroxyquinoline + Chlorocresol

* fixed dose combination of Betamethasone + Gentamycin + Zinc Sulphate + Clotrimoazole + Chlorocresol

* fixed dose combination of Borax + Boric Acid + Naphazoline + Menthol + Camphor + Methyl Hydroxy Benzoate

* fixed dose combination of Bromhexine + Dextromethorphan

* fixed dose combination of Dextromethophan + Chlopheniramine + Bromhexine

* fixed dose combination of Menthol + Anesthetic Ether

* fixed dose combination of Dextrometharphan + Chlopheniramine + Ammonium + Sodium Citrate + Menthol

* fixed dose combination of Ergotamine Tartrate + Belladona Dry Extract+Caffeine + Paracetamol

* fixed dose combination of Phenytoin + Phenobarbitone

* fixed dose combination of Gliclazide 40mg + Metformin 400mg

* fixed dose combination of Paracetamol + Ambroxol + Phenylephrine + Chlorpheniramine

* fixed dose combination of Oflaxacin + Ornidazole Suspension

* fixed dose combination of Albuterol + Etofylline + Bromhexine + Menthol

* fixed dose combination of Albuterol + Bromhexine + Theophylline

* fixed dose combination of Salbutamol+Hydroxyethyltheophylline (Etofylline) + Bromhexine

* fixed dose combination of Paracetamol+Phenylephrine+Levocetirizine+Sodium Citrate

* fixed dose combination of Paracetamol + Propyphenazone + Caffeine

* fixed dose combination of Guaifenesin + Diphenhydramine + Bromhexine + Phenylephrine

* fixed dose combination of Dried Alumnium Hydroxie Gel + Prophantheline + Diazepam

* fixed dose combination of Bromhenxine + Phenylephrine + Chlorpheniramine + Paracetamol

* fixed dose combination of Beclomethasone + Clotrimazole + Gentamicin + lodochlorhydroxyquinoline

* fixed dose combination of Telmisartan + Metformin

* fixed dose combination of Ammonium Citrate + Vitamin B 12 + Folic Acid + Zinc Sulphate

* fixed dose combination of Levothyroxine + Phyridoxine + Nicotinamide

* fixed dose combination of Benfotiamine + Metformin

* fixed dose combination of Thyroid + Thiamine + Riboflavin + Phyridoxine + Calcium Pantothenate + Tocopheryl Acetate + Nicotinamide

* fixed dose combination of Ascorbic Acid + Manadione Sodium Bisulphate + Rutin + Dibasic Calcium Phosphate + Adrenochrome mono Semicarbazone

* fixed dose combination of Phenylephrine + Chlorpheniramine + Paracetamol + Bromhexine + Caffeine

* fixed dose combination of Clotrimazole + Beclomethasone + Lignocaine + Ofloxacin + Acetic Aicd + Sodium Methyl Paraben + Propyl Paraben

PrEP could prevent 185,000 new HIV infections

Increasing diagnosis, care and treatment of people living with HIV could lead to a large decrease in HIV incidence, preventing some 168,000 new infections by the year 2020, according to a new US Centers for Disease Control and Prevention (CDC) analysis presented at the Conference on Retroviruses and Opportunistic Infections (CROI 2016) last week in Boston. The impact of pre-exposure prophylaxis (PrEP) would be comparatively modest, but its importance would be greater if more people with HIV are not on treatment with undetectable viral load.

Emine Yaylali of the CDC and colleagues developed a dynamic model of HIV transmission, looking at what would happen if 90% of people living with HIV are diagnosed, 85% are linked to care and 80% start antiretroviral therapy (ART) and achieve viral suppression – key goals in the continuum of care outlined in the US National HIV/AIDS Strategy.

Studies have shown that the risk of HIV transmission is reduced to almost zero when people with HIV are on ART that successfully suppresses viral load, and consistent use of tenofovir/emtricitabine (Truvada) as PrEP has been shown to decrease the likelihood of HIV-negative people acquiring HIV to a similar extent. But the relative contribution of these interventions in controlling local and national HIV epidemics is unknown.

The researchers started with the estimate that 87% of people with HIV were diagnosed, 80% were linked to care and 36% of those diagnosed had achieved viral suppression in 2015.

They then assessed the effect of raising these percentages to the National HIV/AIDS Strategy goals, based on the 96% reduction in the risk of new infections in the HPTN 052 study of serodiscordant heterosexual couples when the partner with HIV was on effective ART.

They also looked at the benefit of PrEP used by 40% of high-risk men who have sex with men (MSM), 10% of people who inject drugs and 10% of high-risk heterosexuals. For efficacy, they used the 73% risk reduction in the iPrEx trial for MSM with detectable tenofovir/emtricitabine drug levels, 75% in the Partners PrEP trial for heterosexual couples, and 49% in the Bangkok Tenofovir Study for people who inject drugs.

The model predicted that increasing the number of people on ART with undetectable viral load would, by itself, prevent more than 168,000 new infections by 2020.

Expanding PrEP would avert approximately 17,000 additional infections over the next five years. Together, expanded treatment and PrEP would prevent 185,000 new infections – a 70% reduction.

However, if diagnosis and treatment rates remained stable at 2015 levels, expanded use of PrEP alone could potentially prevent 48,000 new infections, showing that its impact is greater if more people with HIV remain off treatment with detectable viral load.

“If we expand the use of our current prevention strategies today, we can significantly reduce new HIV infections tomorrow,” Jonathan Mermin, director of CDC’s National Center for HIV/AIDS, Viral Hepatitis, STD, and Tuberculosis Prevention, stated in a CDC press release. “This study confirms that we have the right tools to dramatically reduce new HIV infections, but we have a long way to go in order to make those reductions a reality.”

“We urgently need to close gaps in HIV care and treatment for people living with HIV,” added Eugene McCray, director of CDC’s Division of HIV/AIDS Prevention. “At the same time, in the short term, we need to rapidly expand access to PrEP and other life-saving prevention tools.”

HIV hides and grows inside the body even when undetectable in blood

HIV can hide and grow in body ‘sanctuaries’ after disappearing from blood, study says

Researchers pinpoint how HIV hides and grows inside the body even when undetectable in blood

HIV continues to replicate in the body even if it’s undetectable in the blood after antiretroviral treatment, scientists have discovered.

It explains how the virus rapidly bounces back – and keeps growing – after a patient stops taking antiretroviral drugs.

Study author Dr Steven Wolinsky, chief of infectious diseases at Northwestern’s Feinberg School of Medicine, said: ‘We now have a path to a cure.

‘The challenge is to deliver drugs at clinically effective concentrations to where the virus continues to replicate within the patient.’

Potent antiretroviral drugs are able to seemingly get rid of HIV from the bloodstream in most patients.

After the treatment, their blood tests may not detect the virus.

However, HIV is still growing in a viral reservoir within the lymphoid tissue in the body at that time.

And, it ‘quickly rebounds’ in the blood after patients stop taking the drugs.

Scientists concluded that latently infected cells or ongoing low levels of HIV replication maintain those viral reservoirs during antiretroviral treatment.

Scientists long believed that the reservoir only contained long-infected cells in a resting place – instead of newly infected cells.

That’s because none of them had seen viruses with new genetic mutations that arise when HIV completes its growth cycles.

Furthermore, most patients don’t develop drug resistant mutations – which would seem likely if HIV was growing in the presence of drugs.

The study analyzed viral sequences in serial samples of lymph node cells.

They also examined blood from three HIV-infected patients.

Each of those patients had no detectable virus in their blood.

The scientists determined that the viral reservoir was constantly replenished by low-level virus replication in the lymphoid tissue.

Infected cells would then move from those ‘protected sanctuaries’ and into the blood, they found.

Therefore, infected cells in drug-sanctuaries within the lymphoid tissue can still produce new viruses.

HOW HIV INFECTS

HIV infects CD4+ T-cells, which play a vital role in the immune system and protect us from diseases. As HIV progresses, it reduces the number of active T-cells in the body until the immune system cannot function correctly, a state known as 'acquired immune deficiency syndrome' or AIDS.

Current World Health Organisation guidelines, which the UK government follows, recommend only beginning HIV treatment when the number of T-cells in the bloodstream falls below a certain level.

However, the new model predicts that treatment should start as soon as possible after infection to prevent AIDS from developing in the long term.

They can also infect new target cells and replenish the viral reservoir.

That’s why drugs have not been able to completely purge the body of latently infected cells – and kill the virus all together.

The scientists utilized a mathematical model to track the amount of the virus and number of infected cells as they grew in the sanctuaries – and as they then moved through the body.

The model showed that HIV grows in areas where antiretroviral drug concentrations are lower than in the blood.

The scientists concluded that it is important to deliver high concentrations of antiretroviral drugs to all locations in the body where HIV may grow and evolve.

As such, drugs that penetrate these ‘newly discovered sanctuaries’ will be required to eliminate the viral reservoir – and may bring the medical community closer to finding a cure.

Co-author Dr Angela McLean, a professor of mathematical biology at Oxford University, said: ‘The study is exciting because it really changes how we think about what is happening in treated patients.

‘It helps explains why some strategies that tried to clear the reservoir have failed.’

The study was published in the journal Nature. 

A new study shows that HIV can still live and grow in the body even after disappearing from the blood following aggressive antiretroviral therapy.

The research, published in the journal Nature on Wednesday, involved looking at samples of cells from the lymph nodes of three patients who appeared to have cleared the virus. The researchers found that cells in the lymph node tissue can still produce new viruses and infect new target cells.

The groundbreaking idea of viral reservoirs of HIV made headlines in July 2014 when a Mississippi girl born with HIV, who was believed to be cured after early treatment, tested positive for the virus after stopping therapy. In her case, doctors think the infection reemerged from a viral reservoir that contained cells in a resting state that were not proliferating.

The latest study, funded by the US National Institutes of Health, appears to show a different type of “sanctuary,” as the researchers called it, that harbours cells with low levels of HIV replication that move into the blood. Researchers used a mathematical model to track the amount of virus and the amount of infected cells as they grew and moved through the body.

This suggests that virus growth could occur in a place where drug concentrations are very low.

“These findings are important as it is critical for the field of HIV cure research to know whether new infectious cycles are indeed continuing in patients on seemingly effective treatment,” said Deborah Persaud, a professor of infectious diseases at Johns Hopkins University School of Medicine.

But Persaud, who was not involved in the lymph node research but was part of a team caring for a baby who had received a treatment similar to the Mississippi child, said the study is limited by its small sample size and the fact that the analyses were done during the first six months of combination treatment “when the infected pools are still very dynamic.” She said a similar study on patients with longer-term treatment may offer more clues about what is going on.

Co-author Steven Wolinsky, chief of infectious diseases at Northwestern University Feinberg School of Medicine and a Northwestern Medicine physician, said in a statement that the research indicates that “the challenge is to deliver drugs at clinically effective concentrations to where the virus continues to replicate within the patient.”

Angela McLean, a professor of mathematical biology at Oxford University and who supervised the mathematical modeling, added that the study “really changes how we think about what is happening in treated patients.”

“It helps explain why some strategies that tried to clear the reservoir have failed,” she said.